Ocimum sanctum, an Indian medicinal plant, has been studied for its role in diabetes and its effect on lipid profile. This study was conducted to elucidate whether treatment of Ocimum sanctum Leaf extract after streptozotocin (STZ) - induced diabetes has anti-hyperglycemic and anti-dyslipidaemic action or not. The experiment involved four groups of rat; one group was control group, second diabetic control, third diabetic group received alcoholic extract of OS and fourth diabetic group received glibenclamide as a reference standard. Oral glucose tolerance test was performed before induction of diabetes. Blood was collected by retro-orbital puncture for glucose estimation, and to evaluate serum triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol levels. The results show that blood glucose level rather than decreasing, were significantly elevated after the treatment. Serum lipid profile parameters such as total-cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein cholesterol were also elevated, whereas, the level of high-density lipoprotein-cholesterol was reduced significantly (P<0.05) in diabetic rat. Ethanolic extract of OS after induction of diabetes, normalized lipid profile. It can be concluded that STZ-induced hyperglycaemia can not ameliorated by treatment with ethanolic extract of OS. OS ethanolic leaves extract after diabetic induction, reverses dyslipidaemia and partially protects liver function.
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